Virus-targeted biocatalysts

Details Virus-targeted biocatalysts Virus-targeted biocatalysts

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/73 (2006.01) C12N 9/14 (2006.01) C12N 9/72 (2006.01) C12N 9/74 (2006.01) C12N 15/13 (2006.01) C12N 15/55 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2130832

This invention pertains to biocatalysts that are specifically targeted to bind pathogens, such as viruses, and to degrade components of pathogens in order to abrogate their pathogenicity, and to methods of preventing or treating infection by pathogenic organisms. The biocatalysts comprise a binding agent which specifically binds a surface component of a pathogen, for instance the gp120 viral coat protein of HIV, the Human Immunodeficiency Virus, and a catalytic moiety which degrades a component of the pathogen so that its pathogenicity is abrogated. The binding agent and the catalytic moiety are linked by chemical linkers or genetic engineering techniques.

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