Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 401/02 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) C07D 235/30 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2312366

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemoterapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

L'invention concerne des composés qui inhibent la farnésyl-protéine transférase (Ftase) et la farnélysation de la protéine Ras oncogène. L'invention concerne également des composés chimiothérapeutiques contenant les composés de l'invention et des procédés d'inhibition de la farnésyl-protéine transférase et la farnélysation de la protéine Ras oncogène.

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