Chimaeric influenza-hiv vaccine

Details Chimaeric influenza-hiv vaccine Chimaeric influenza-hiv vaccine

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/21 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C12N 15/49 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2057963

68/GHB18 18254 TITLE OF THE INVENTION CHIMAERIC INFLUENZA-HIV VACCINE ABSTRACT OF THE DISCLOSURE The exposed and highly immunogenic A-antigenic loop of influenza hemagglutinin (HA) is homologous with a Principal Neutralizing Determinant (PND) present on the Human Immunodeficiency Virus' (HIV) envelope glycoprotein, gp120. Inoculation of a mammal with a killed or attenuated virus, or purified HA protein, modified so as to convert the HA A-antigenic site into an HIV PND, produces the usual strong response to the HA site A, but the antibody produced is specific to the hemagglutinin-HIV PND chimaera, and is useful to neutralize HIV.

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