Pyridyl derivatives and their use as therapeutic agents

Details Pyridyl derivatives and their use as therapeutic agents Pyridyl derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/444 (2006.01) A61P 3/06 (2006.01) C07D 213/71 (2006.01) C07D 213/76 (2006.01)

Patent

CA 2533900

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is -O-, - N(R1)-, C(O) , S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2 , S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1) ; and V is C(O) , C(S) , C(O)N(R1)-, C(O)O-, S(O)2- , S(O)2N(R1)- or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

L'invention concerne des méthodes destinées à traiter une maladie ou un état à médiation de stéaroyl-CoA-désaturases chez un mammifère, de préférence un humain. Les méthodes selon l'invention consistent à administrer à un mammifère un composé de formule (I) : dans laquelle x, y, W, V, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?7a¿, R?8¿, R?8a¿, R?9¿, R?9a¿, R?10¿ et R?10a¿ sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés de formule (I).

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