C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/497 (2006.01) A61K 31/554 (2006.01) C07D 471/20 (2006.01)
Patent
CA 2735821
Compounds of formula (I): wherein variables B, m, n, J, R4, Ea, Eb, Ec, Re, Rf; R PG and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
L'invention porte sur des composés de formule (I) : dans laquelle des variables B, m, n, J, R4, Ea, Eb, Ec, Re, Rf, RPG et Y sont telles que celles décrites présentement, qui sont des antagonistes des récepteurs CGRP et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles le CGRP est mis en jeu, telles que la migraine. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement de telles maladies dans lesquelles le CGRP est mis en jeu.
Bell Ian M.
Selnick Harold G.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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