Ether lipid-nucleoside covalent conjugates

Details Ether lipid-nucleoside covalent conjugates Ether lipid-nucleoside covalent conjugates

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) C07F 9/10 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2085354

Ether lipid nucleoside covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'-Azido-3'-deoxythymidine- 5'-monophosphate-D,L-3 octadecanamido-2-ethoxypropane and 3'-Azido-3'- deoxythymidine-5' butyrate-y-N,N,N-trimethyl-am- monium-.beta.-(1-phospho-2-ethoxy-3-hexadecylozypropane).

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