Sustained release drug dispersion delivery device

Details Sustained release drug dispersion delivery device Sustained release drug dispersion delivery device

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2378829

The present invention is related to a drug delivery device, that is pH insensitive, for the sustained <i>in situ</i> production and release of a dispersion, in an environment of use, which comprises a) a compressed core prepared from an admixture comprising i) a therapeutically effective amount of a beneficial agent that has a solubility profile that is dependent on the pH level of the environment of use; ii) a water swellable polymer which upon hydration forms gelatinous microscopic particles; and iii) a pH modulator; and b) a water insoluble, water impermeable polymeric coating comprising a polymer and a plasticizer, which surrounds and adheres to the compressed core, said water insoluble, water impermeable polymeric coating having at least one aperture.

La présente invention porte sur un dispositif d'administration de médicaments, insensible au pH, et permettant de générer et de libérer <i>in situ</i> de manière prolongée une dispersion, dans un environnement d'utilisation. Ce dispositif comprend a) une partie centrale comprimée préparée à partir d'un mélange comprenant : i) une quantité efficace d'un point de vue thérapeutique d'un agent bienfaisant dont le profil de solubilité dépend du taux du pH de l'environnement d'utilisation; ii) un polymère pouvant gonfler dans l'eau et qui, lors de l'hydratation, forme des particules microscopiques gélatineuses; et iii) un modulateur de pH; et b) un revêtement polymère imperméable à l'eau, insoluble dans l'eau, comprenant un polymère et un plastifiant et qui entoure la partie centrale comprimée en adhérant à celle-ci, ce revêtement polymère comportant au moins un orifice.

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