Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds

Details Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2146260

The present invention is directed to compounds of formula (I), and the pharmaceutically acceptable acid addition salts thereof, wherein R is selectetd from the group consisting of F, -CF3, -OCH3, -O(C1)alkyl substituted with 1 to 3 fluoro atoms, -O(C2)alkyl substituted with 1 to 5 fluoro atoms, and -O(C3)alkyl substituted with 1 to 7 fluoro atoms. The compounds of formula (I) are useful in the treatment of stroke, traumatic brain injury and central nervous system degenerative diseases.

La présente invention concerne des composés de formule (I), et les sels d'addition acide pharmaceutiquement acceptables de ces derniers, où R est choisi parmi le groupe constitué de F, -CF3, -OCH3, -O-alkyle en C1 substitué par 1 à 3 atomes de fluor, -O-alkyle en C2 substitué par 1 à 5 atomes de fluor, et -O-alkyle en C3 substitué par 1 à 7 atomes de fluor. Les composés de formule (I) sont utiles dans le traitement des accidents cérébro-vasculaires, des traumatismes cérébraux et des maladies dégénératives du système nerveux central.

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