Degradable heterobifunctional poly(ethylene glycol)...

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 65/00 (2006.01) A61K 9/06 (2006.01) A61K 38/00 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2316834

A heterobifunctional polyethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.

L'invention concerne un polyéthylèneglycol hétérobifonctionnel présentant une liaison dégradable par hydrolyse, une première terminaison comprenant un groupe acrylate, et une seconde terminaison comprenant une cible telle qu'une protéine ou un agent pharmaceutique, ou bien une fraction réactive pouvant se lier à une cible. L'invention concerne également la préparation d'hydrogels. Ces hydrogels peuvent être utilisés comme vecteurs pour une protéine ou un agent pharmaceutique qui peut être facilement libéré de façon contrôlée.

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