Use of interleukin-24 to treat ovarian cancer

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2480176

The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-24 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-24 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.

La présente invention concerne l'activité anticancéreuse de molécules polypeptidiques de l'IL-24. L'IL-24 est une cytokine impliquée dans des procédés inflammatoires et dans des maladies humaines. La présente invention consiste à utiliser l'IL-24 pour diminuer la prolifération de cellules cancéreuses de l'ovaire, pour traiter le cancer de l'ovaire, entre autres utilisations. Des polypeptides de l'IL-24 peuvent être administrés seuls, ou peuvent être fusionnés à des fractions cytotoxiques, et ils peuvent être administrés conjointement avec un rayonnement ou avec des agents chimiothérapeutiques.

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