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C - Chemistry, Metallurgy

07

K

530/7.08, 530/7.

C07K 14/595 (2006.01) A61K 38/04 (2006.01) A61K 38/22 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2030212

ABSTRACT OF THE DISCLOSURE A method for controlling the growth of tumor tissues, especially small cell lung and prostatic carcinomas, and gastric acid secretion, causative and symptomatic of, peptic (esophageal, gastric, and duodenal) ulcers. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin/GRP type inhibitor. Antagonists of bombesin/GRP which are derivatives of naturally occurring bombesin/GRP possessing a thiomethylene or methylene sulfoxide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which bombesin/GRP is implicated is also described. M01439 A

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