G - Physics – 01 – N
Patent
G - Physics
01
N
167/129, 167/139
G01N 23/00 (2006.01) C07K 16/26 (2006.01) G01N 33/48 (2006.01) G01N 33/78 (2006.01)
Patent
CA 1050425
Abstract of the Disclosure An improved, simplified radioimmunoassay method for the in vitro determination of L-triiodo- thyronite in unextracted blood serum involves the use of a combination reagent constituted by a buffered solution containing radioactive L-triiodothyronine and an inhibitor for inhibiting binding of L-triiodothyro- nine to thyroxine-binding globulin. Optionally the re- agent may also include an antiserum contaning antibody capable of immunoreactivity with L-triiodothyronine. Packaged test kits for use in conveniently carrying out the radioimmunoassay are also provided. Certain salts of 8-anilino-1-naphthalene sulfonic acid, which may be regarded as purified forms of the acid, are preferably employed as inhibitors for inhibiting bind- ing of L-triiodothyronine to thyroxine-binding globu- lin. An improved radioimmunoassay method for the in vitro determination of thyroxine in unextracted blood serum is characterized by the use of an antiserum con- taining antibody capable of immunoreactivity with thyroxine and prepared from an immunogen comprising a conjugate of the N-acetyl derivative of thyroxine coupled to bovine serum albumin with 1-ethyl-3-(3-dimethylaminopropyl)- carbodiimide.
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