The use of phthalide derivatives

Details The use of phthalide derivatives The use of phthalide derivatives

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2624150

Disclosed a class of phthalide derivatives and the use of which to manufacture the sensitizer or reverser of the antineoplastic agent. The phthalide derivatives according to the invention can enhance the sensitivity of drug- resistance tumor cells against chemotherapy and decrease the drug-resistance of tumor cells 5-30 folder and enhance notably several chemotherapy agents- induced apoptosis of tumor cells.

La présente invention concerne une classe de dérivés du phthalide et l~utilisation de celle-ci en vue de fabriquer le sensibilisateur ou le révertant de l~agent antinéoplasique. Les dérivés du phthalide selon cette invention peuvent augmenter la sensibilité des cellules tumorales pharmacorésistantes vis-à-vis de la chimiothérapie et réduire de 5 à 30 fois la pharmacorésistance des cellules tumorales, ainsi que favoriser de manière significative l~apoptose de cellules tumorales induites par plusieurs agents de chimiothérapie.

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