Humanised antibodies directed against a33 antigen

Details Humanised antibodies directed against a33 antigen Humanised antibodies directed against a33 antigen

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C12N 15/13 (2006.01) C12N 15/28 (2006.01)

Patent

CA 2128544

2128544 9413805 PCTABS00032 A33 antigen binding proteins are described for use in the diagnosis or treatment of colorectal tumours and metastases arising therefore. The binding protein may be a humanised A33 antibody, incl uding complete antibody molecules, fragments thereof, and, especially, multivalent monospecific proteins comprising two, three, four or more antibodies or fragments thereof bound to each other by a cross-linking agent. For diagnosis or therapy the humanised A33 antibody may be linked to a reporter or effector molecule.

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