Monoclonal antibodies reactive with a human atheroma...

C - Chemistry – Metallurgy – 12 – P

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167/129, 167/37,

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/775 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2032359

X-8089A Abstract The present invention relates to a naturally occurring, minimally modified LDL antigen which is present in human atherosclerotic lesions as well as in the serum of a high percentage of patients with coronary artery disease. The invention also comprises antibodies reactive with the antigen, hybridoma cell lines that produce the antibodies of the invention, and methods for using the antibodies in the diagnosis and treatment of atherosclerotic disease.

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