Oral dosage formulations comprising (2s,3s,5r) -2-(3,5-...

A - Human Necessities – 61 – K

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Details

A61K 31/537 (2006.01) A61K 9/20 (2006.01) A61K 31/5375 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2345638

This invention provides discrete oral dosage forms, typically tablets or capsules, containing (2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2- morpholinol or a physiologically acceptable salt or solvate thereof, or a solvate of said salt, and an effective stabilizing amount of alginic acid. These dosage forms are useful for preventing or treating attention deficit hyperkinetic disorder or depression, or in the treatment of addiction to nicotine-containing products, especially tobacco-containing products, such as aiding in smoking cessation.

L'invention concerne des formes posologiques discrètes à administration par voie orale, généralement des comprimés ou des gélules, contenant le composé (2S,3S,5R)-2-(3,5-difluorophényl)-3,5-diméthyl-2-morpholinol ou un sel ou solvate physiologiquement acceptable de ce composé, ou un solvate dudit sel, et une quantité stabilisante efficace d'acide alginique. Ces formes posologiques sont utiles pour prévenir ou traiter l'hypercinésie avec déficit de l'attention ou la dépression, ou pour traiter l'accoutumance à des produits contenant de la nicotine, en particulier des produits contenant du tabac, afin d'aider, par exemple, un patient à s'arrêter de fumer.

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