Phenanthrene derivatives as mpges-1 inhibitors

Details Phenanthrene derivatives as mpges-1 inhibitors Phenanthrene derivatives as mpges-1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4188 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2652238

The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmacuetical compositions are also encompassed.

L'invention concerne de nouveaux composés de formule ou des sels pharmaceutiquement acceptables de ceux-ci. Ces composés sont des inhibiteurs de l'enzyme prostaglandine E synthase-1 microsomale (mPGES-1) et sont par conséquent utiles pour traiter la douleur et/ou l'inflammation créées par une diversité de maladies ou d'états, telles que l'ostéo-arthrite, la polyarthrite rhumatoïde et la douleur aiguë ou chronique. L'invention concerne également des procédés de traitement de maladies ou d'états à médiation par l'enzyme mPGES-1 et des compositions pharmaceutiques.

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