C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 35/00 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2331889
The present invention relates to BUB1 and NEK kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a targeted PCR cloning strategy, the human BUB1 serine/threonine kinase was identified and its protein structure was predicted. Additionally, through the use of a bioinformatics strategy, three mammalian members of the NEK-subfamily of STK's have been identified and their protein structure predicted.
L'invention concerne de polypeptides de BUB1 kinases et de NEK kinases, des séquences de nucléotides codant pour lesdits polypeptides, ainsi que divers produits et techniques utiles pour le diagnostic et le traitement de divers états et pathologies liés aux kinases. L'utilisation d'une stratégie de clonage à base de PCR ciblée a permis d'identifier la sérine-thréonine kinase (STK) BUB1 humaine et de prédire sa structure protéique. L'utilisation d'une stratégie bio-informatique a permis d'identifier trois membres de la sous-famille NEK des STK de mammifère et de prédire leur structure protéique.
Martinez Ricardo
Plowman Gregory
Zhu Yingfang
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sugen Inc.
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