Sulphonylpiperidine derivatives containing an alkenyl or...

Details Sulphonylpiperidine derivatives containing an alkenyl or... Sulphonylpiperidine derivatives containing an alkenyl or...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61P 37/00 (2006.01) C07D 211/96 (2006.01) C07D 239/26 (2006.01)

Patent

CA 2492251

A compound of formula (1): wherein B is optionally substituted C2-4alkenyl or C2-4alkynyl; useful in the inhibition of one or more metalloproteinases and in particular TACE.

Cette invention a trait à un composé correspondant à la formule (I). Dans cette formule, B représente un alcényle ou n alkynyle ayant de 2 à 4 atome de carbone, éventuellement substitué. Ce composé se révèle des plus utile s'agissant d'inhiber une ou plusieurs métalloprotéases, notamment l'enzyme de conversion de facteur de nécrose tumorale .alpha. (TACE).

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