Improved nitroreductase enzymes

Details Improved nitroreductase enzymes Improved nitroreductase enzymes

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 38/44 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2458226

Improved nitroreductase enzymes, particularly for use as prodrug converting enzymes are provided. In particular, single and double mutants of the E.coli NFSB nitroreductase, having improved properties for the activation of the prodrug CB1954 for use in gene therapy are disclosed.

L'invention concerne des enzymes de nitroréductase utilisées notamment comme enzymes de conversion de promédicament. L'invention concerne, en particulier, des mutants simples et doubles de nitroréductase NFSB de <i>E.coli</i> possédant des propriétés améliorées d'activation du promédicament CB1954 utilisé en thérapie génique.

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