Quinoline-containing ketoacids as leukotriene antagonists

C - Chemistry – Metallurgy – 07 – D

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C07D 215/18 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2061675

Compounds having the formula I: Image are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection.

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