Coating composition for polymeric surfaces comprising serpin...

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A61L 27/34 (2006.01) A61L 33/00 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2556785

The invention relates generally to a coating composition for a polymeric surface, methods for coating a polymeric surface, methods for preparing coated medical devices, polymeric surfaces coated with the coating composition, and medical devices comprising the coating composition. In particular, a coating composition for association with a polymeric surface, preferably a polymeric surface of a medical device, is described comprising a cross-linked basecoat displaying a plurality of active groups in association with a serpin or serpin derivatives, wherein the serpin or serpin derivatives are not substantially cross-linked with other serpin or serpin derivatives.

L'invention porte d'une manière générale: sur une composition de revêtement de surfaces polymériques, sur des procédés de revêtement de surfaces polymériques, sur des procédés de préparation de dispositifs médicaux revêtus, sur des surfaces polymériques ainsi revêtues, sur des dispositifs médicaux revêtus de ladite composition, et en particulier sur une composition de revêtement associable à une surface polymérique, de préférence à celle d'un dispositif médical, comprenant une couche de base réticulée présentant plusieurs groupes actifs associés à une serpine ou à ses dérivés, la serpine ou ses dérivés n'étant pas substantiellement réticulés avec d'autres serpines ou dérivés de serpine.

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