Benzoyl-tetrahydropyridine as glyt-1 inhibitors

Details Benzoyl-tetrahydropyridine as glyt-1 inhibitors Benzoyl-tetrahydropyridine as glyt-1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/4418 (2006.01) A61K 31/5377 (2006.01) A61P 25/28 (2006.01) C07D 211/70 (2006.01)

Patent

CA 2594260

The present invention relates to compounds of the general formula (I); Wherein R1 is a non aromatic heterocycle or OR'; R~ is lower alkyl, lower alkyl substituted by halogen or is -(CH2)n -cycloalkyl; R2 is NO2, CN or SO2R"; R" is lower alkyl; Ar is phenyl, optionally substituted by halogen, cyano, lower alkyl substituted by halogen or SO2 R"; n is 0, 1 or 2; and to pharmaceutically active acid addition salts and to there use in the treatment of neurological and neuropsychiatry disorders.

La présente invention concerne des composés de formule générale (I), dans lesquels R1 est un hétérocycle non aromatique ou OR'; R~ est un alkyle inférieur, un alkyle inférieur remplacé par un halogène ou est un cyclo-alkyle -(CH2)n ; R2 est NO2, CN ou SO2R" ; R" est un alkyle inférieur ; Ar est un phényle, remplacé facultativement par un halogène, un cyano, un alkyle inférieur remplacé par un halogène ou SO2 R" ; n est 0, 1 ou 2 ; et des sels d~addition actifs d~un point de vue pharmaceutique et leur utilisation dans le traitement de troubles neurologiques et neuropsychiatriques.

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