Compositions and methods of treatment for inflammatory diseases

A - Human Necessities – 61 – K

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A61K 31/606 (2006.01) A61K 31/13 (2006.01) A61K 31/198 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2553775

Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5- aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases or other inflammatory bowel diseases.

Les maladies intestinales inflammatoires sont représentées par deux dysfonctionnements idiopathiques qui comprennent la colite ulcéreuse et la maladie de Crohn. La colite ulcéreuse se limite au colon et implique l'inflammation de la paroi (muqueuse) du gros intestin. La maladie de Crohn, d'autre part, peut concerner la muqueuse de l'intestin grêle et/ou du gros intestin, et peut concerner des couches profondes de la paroi intestinale. L'invention concerne une combinaison d'acide 5-aminosalicylique et d'un ou plusieurs antioxydants (par ex. N-acétylcystéine) pour traiter ces maladies intestinales inflammatoires ou d'autres maladies intestinales inflammatoires.

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