C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/22 (2006.01) A61K 31/341 (2006.01) A61K 31/443 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2616854
The present invention is directed to cyclic ketal compounds of formula (I); which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
La présente invention concerne des composés de cétal cyclique de formule (I), lesquels composés sont des inhibiteurs de l'enzyme bêta-sécrétase et sont utiles dans le traitement de maladies dans lesquelles cette enzyme bêta-sécrétase est impliquée, telles que la maladie d'Alzheimer. Cette invention se rapporte également à des compositions pharmaceutiques comprenant ces composés ainsi qu'à l'utilisation desdits composés et desdites compositions dans le traitement de ces maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée.
Nantermet Philippe G.
Vacca Joseph P.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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