Prostate specific antigen substrates

Details Prostate specific antigen substrates Prostate specific antigen substrates

G - Physics

01

N

G01N 33/68 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12N 9/64 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2284137

The present invention relates to improved prostate specific antigen substrates, and provides for a method of purifying such substrates as well as compositions comprising the substrates themselves. These substrates may be used in assays which measure prostate specific antigen activity. Such assays may provide a clinical evaluation of patients suffering from, or at risk for, prostate cancer, and also may be used to identify therapeutically useful inhibitors of prostate specific antigen activity.

L'invention concerne des substrats d'antigène prostatique spécifique et un procédé pour purifier ces substrats, ainsi que compositions contenant ces substrats. Ces substrats peuvent être utilisés dans des procédés de mesure de l'activité antigénique spécifique à la prostate. De tels procédés permettent de réaliser une évaluation clinique de patients atteints ou présentant un risque de cancer de la prostate, et peuvent également servir à identifier des inhibiteurs thérapeutiquement utiles de l'activité de l'antigène prostatique spécifique.

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