Specific antibodies against mammary tumor-associated mucin,...

Details Specific antibodies against mammary tumor-associated mucin,... Specific antibodies against mammary tumor-associated mucin,...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Type

Patent

Patent number

CA 2319688

Description

An immunologically active polypeptide which specifically binds to the carbohydrate structure of the MUC1 tandem repeat from carcinoma cells, wherein a) the quotient between the affinity of the said polypeptide for a 200 to 440 kDa glycoprotein fraction from tumor cell-containing ascites of breast cancer patients and for native MUC1 antigen (400 to 440 kDa) from normal cells is 100:1 or more, b) the polypeptide does not bind to nonglycosylated MUC1 antigen, and c) the binding of the polypeptide to the said 200 to 440 kDa glycoprotein fraction changes by 10 % or less if the glycoprotein fraction was treated with neuraminidase to cleave N-terminal neuraminic acids, or with formalin. The immunologically active polypeptide, e.g. antibody, is useful in the diagnosis and therapy of breast cancer.

Polypeptide à activité immunologique, qui se lie spécifiquement à la structure glucidique des séquences MUC1 répétées en tandem provenant de cellules carcinomateuses, pour lequel: a) le quotient de l'affinité du polypeptide d'une part pour une fraction glycoprotéique de 200 à 440 kDa provenant du liquide d'ascite riche en cellules de patientes atteintes d'un cancer du sein et d'autre part pour l'antigène MUC1 natif (400 à 440 kDa) provenant de cellules normales est égal ou supérieur à 100/1; b) le polypeptide ne se lie pas à l'antigène MUC1 non glycosylé; et c) la liaison du polypeptide à la fraction glycoprotéique de 200 à 440 kDa est modifiée de 10 % ou moins si ladite fraction a été traitée par la neuraminidase, qui clive les acides neuraminiques N-terminaux, ou par la formaline. Ce polypeptide spécifique de MUC1 est utile pour le diagnostic et le traitement du cancer du sein.

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