C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/22 (2006.01) C07C 237/42 (2006.01) C07C 255/60 (2006.01) C07C 257/18 (2006.01) C07C 275/34 (2006.01) C07C 311/44 (2006.01) C07D 207/27 (2006.01) C07D 211/76 (2006.01) C07D 213/64 (2006.01) C07D 233/36 (2006.01) C07D 237/14 (2006.01) C07D 263/22 (2006.01) C07D 265/28 (2006.01) C07D 265/32 (2006.01) C07D 271/06 (2006.01) C07D 271/07 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2439644
Compounds of the formula (I) in which R1 is CN, or C(=NH)-NH2, CON(R3)2 or [C(R4)2]nN(R3)2, each of which is unsubstituted or monosubstituted by C(=O)R3, COOR3, or3 or by a conventional amino-protecting group, or W is -NR3CO-, - NR3COC(R4)2, NR3C(R4)2) or -C(R4)2NR3C(R4)2-, X is -C(R3)2-, -[C(R3)2]2-, - C(R3)2O- or -C(R3)2NR3, Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl, T is OR3, N(R3)2, N(R3)2CON(R3)2, a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic radical having from 1 to 4 N, O and/sor S atoms which is unsubstituted or monosubstituted, disubstituted or trisubstituted, or a phenyl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.
Composés correspondant à la formule (I) dans laquelle R?1¿ est CN, ou C(=NH)-NH¿2?, CON(R?3¿)¿2? ou [C(R?4¿)¿2?]¿n?N(R?3¿)¿2?, chacun étant non substitué ou monosubstitué par C(=O)R?3¿, COOR?3¿ ou ?3¿ ou par un groupe protecteur d'amines conventionnel, ou W est -NR?3¿CO-, -NR?3¿COC(R?4¿)¿2?, NR?3¿C(R?4¿)¿2) ou -C(R?4¿)¿2?NR?3¿C(R?4¿)¿2?-, X est -C(R?3¿)¿2?-, -[C(R?3¿)¿2?]¿2?-, -C(R?3¿)¿2?O- ou -C(R?3¿)¿2?NR?3¿, Y est alkylène, cycloalkylène, Het-diyle ou Ar-diyle, T est OR?3¿, N(R?3¿)¿2?, N(R?3¿)¿2?CON(R?3¿)¿2?, un radical hétérocyclique monocyclique ou bicyclique, saturé, insaturé ou aromatique possédant 1 à 4 atomes N, O et/ou S, qui est non substitué ou monosubstitué, disubstitué ou trisubstitué, ou un radical de phényle qui est non substitué ou monosubstitué, disubstitué ou trisubstitué; ce sont des inhibiteurs du facteur de coagulation Xa qui peuvent s'utiliser dans la prévention et/ou la traitement des troubles thrombo-emboliques et des tumeurs.
Barnes Christopher
Cezanne Bertram
Dorsch Dieter
Gleitz Johannes
Juraszyk Horst
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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