Processes for preparation of maytansinol

Details Processes for preparation of maytansinol Processes for preparation of maytansinol

C - Chemistry, Metallurgy

07

D

C07D 491/12 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2625867

The present invention describes the preparation of maytansinol by methods that minimize processing steps, and reduce solvent volumes, making the process more efficient, and scaleable. This process comprises a step of converting bridged acetals of maytansinol to maytansinol. The simplified processing also aids in lowering the potential for human exposure to chemicals. Also provided is an isolated C3 to C9 bridged acetal of maytansinol.

La présente invention concerne la préparation de maytansinol au moyen de procédés permettant de réduire au minimum les étapes de traitement et de diminuer les volumes de solvant, ce qui rend le procédé plus efficace et mieux adaptable. Ce procédé comprend une étape consistant à convertir les acétals de maytansinol pontés en maytansinol. Le traitement simplifié contribue également à réduire le risque d'exposition humaine à des produits chimiques. L'invention concerne également un acétal ponté C3-C9 de maytansinol.

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