Polynucleotide marker genes and their expression, for...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2614202

The invention discloses isolated endotoxemia marker polynucleotides selected from any one of 163 different polynucleotide sequences, or variants thereof. Endotoxemia related conditions are diagnosed in a test subject by aberrant expression of at least one of the endotoxemia markers or variants thereof. Of practical use, is the early diagnosis of disease, determining those animals at risk of developing endotoxemia, monitoring of an animals immune response to the disease and the enablement of better treatments. Of particular interest is the diagnosis of laminitis in hoofed animals, including horses.

La présente invention conerne des polynucléotides marqueurs de l~endotoxémie isolés sélectionnés parmi 163 séquences de polynucléotides différentes ou variantes de celles-ci. Des maladies relatives à l~endotoxémie sont diagnostiquées chez un sujet test par expression aberrante d~au moins un des marqueurs de l~endotoxémie ou variants de ceux-ci. Le diagnostique précoce de la maladie présente une utilisation pratique en ce qu~il permet de déterminer les animaux risquant de développer l~endotoxémie, de surveiller la réaction immunitaire d~un animal à la maladie et de développer de nouveaux traitements. Le diagnostique de la fourbure chez les ongulés, y compris les chevaux, présente un intérêt particulier.

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