A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 38/00 (2006.01) A61K 38/18 (2006.01)
Patent
CA 2671925
The present invention is directed to sustained release formulations of biologic agents which permit persistent bioavailability. Preferred biologic agents include bone morphogenetic proteins. Diseases susceptible to amelioration and/or treatment with the formulations of the present invention include skeletal tissue diseases such as, but not limited to, osteoarthritis and other osteochondral diseases. The sustained release formulations of the present invention are especially suitable for treatment of minimally-vascularized or non- vascularized tissue sites such as, but not limited to, intrajoint, interarticular, or intraminiscal sites.
La présente invention porte sur des formulations à libération entretenue d'agents biologiques qui permettent une biodisponibilité durable. Les agents biologiques privilégiés comprennent des protéines de morphogenèse de l'os. Les maladies susceptibles d'une amélioration et/ou d'un traitement par les formulations de la présente invention comprennent des maladies du tissu squelettique telles que, mais sans y être limitées, l'ostéoarthrite et d'autres maladies ostéochondrales. Les formulations à libération entretenue de la présente invention sont notamment appropriées pour le traitement de sites de tissu vascularisé au minimum ou non vascularisé tels que, mais sans y être limités, les sites intra-articulaires, inter-articulaires ou intra-méniscaux.
Mbm Intellectual Property Law Llp
Stryker Corporation
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