A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/15 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2598290
The invention provides liquid rotavirus formulations that are suitable for oral administration to human infants. In particular the invention provides pharmaceutical compositions and vaccines, comprising a rotavirus antigen, a sugar and a carboxylate wherein said formulation has a pH of between pH 5.0 and pH 8.0 and comprises no phosphate or less than 5 mM phosphate. The invention also provides methods of preparing said rotavirus formulations and use thereof in the prevention or treatment of rotavirus associated diseases in humans.
La présente invention concerne des formulations liquides de rotavirus qui conviennent pour une administration orale aux nourrissons humains. En particulier, l~invention concerne des compositions pharmaceutiques et des vaccins comprenant un antigène de rotavirus, un sucre et un carboxylate, leur formulation ayant un pH compris entre pH 5.0 et pH 8.0 et ne comprenant pas de phosphate ou moins de 5 mM de phosphate. Cette invention décrit également des procédés de préparation desdites formulations de rotavirus et l~utilisation de celles-ci dans la prévention ou le traitement des maladies associées au rotavirus chez les humains.
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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