Method for identifying compounds useful in the therapy of...

G - Physics – 01 – N

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G01N 33/573 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2384928

A method for identifying a compound useful for the treatment of bone disorders caused by osteoclast differentiation or activation that leads to increased bone resorption, wherein the compound is tested for its ability to inhibit JNK1 synthesis or JNK1 activation and/or c-Jun N-terminal phosphorylation.

L'invention concerne un procédé servant à identifier un composé utile pour le traitement de troubles osseux causés par la différentiation et l'activation des ostéoclastes conduisant à une résorption osseuse accrue. Ce procédé consiste à tester un composé afin de déterminer sa capacité à inhiber la synthèse ou l'activation de la protéine JNK 1 et/ou la phosphorylation de la terminaison c-Jun N.

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