Bioassay for the screening of ion channel active molecules

Details Bioassay for the screening of ion channel active molecules Bioassay for the screening of ion channel active molecules

G - Physics

01

N

G01N 33/566 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61N 5/00 (2006.01) G01N 21/19 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2138380

2138380 9400748 PCTABS00030 This invention relates generally to a bioassay technique to measure the interaction of molecules with ion channels and in particular, sodium channels. More specifically, the present invention relates to the use of circular dichroism to diagnose ion channel, i.e., potassium, calcium and preferably sodium channel disease or dysfunction and a method for screening ion channel active molecules. This invention further provides a novel means to treat cancer associated with diseased dysfunction of ion channels, and especially sodium channel thermal proteins.

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