C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/84 (2006.01) A01H 5/00 (2006.01) A01H 5/10 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C12N 5/04 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) C12N 15/82 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2401965
This invention provides compositions and methods for the transformation of plastids of plant cells with multiple genes, and proper association or assembly of multimeric proteins that are heterologous to the plastids of plant cells. A plasmid construct encoding all of the individual polypeptide components of the multimeric protein is provided. Stable integration of the heterologous coding sequences into the plastid genome of the target plant is accomplished through homologous recombination. The present invention achieves assembly of immunoglobulin heavy and light chains, with covalent bonding between the chains, into immunologically active immunoglobulins in the chloroplast.
L'invention concerne des compositions et des méthodes de transformation des plastes de cellules végétales avec de multiples gènes, et d'association ou d'assemblage des protéines multimériques hétérologues des plastes des cellules végétales. L'invention concerne également un produit de synthèse plasmidique codant pour tous les composants polypeptidiques individuels de la protéine multimérique. L'intégration stable des séquences de codage hétérologues dans le génome plastidial de la plante cible s'effectue par recombinaison homologue. La présente invention concerne l'assemblage de chaînes lourdes et légères d'immunoglobuline, avec liaison covalente entre les chaînes, en immunoglobulines actives d'un point de vue immunologique dans le chloroplaste.
Daniell Henry
Wycoff Keith
Auburn University
Goudreau Gage Dubuc
University Of Central Florida
LandOfFree
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