Lcmv-gp-vsv pseudotyped vectors and tumor infiltrating...

Details Lcmv-gp-vsv pseudotyped vectors and tumor infiltrating... Lcmv-gp-vsv pseudotyped vectors and tumor infiltrating...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) C12N 5/074 (2010.01) A61K 35/76 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2739963

The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

L'invention concerne des virus VSV recombinants et des vecteurs viraux, qui contiennent une glycoprotéine GP du virus de la chorioméningite lymphocytaire (LCMV) au lieu de la protéine G du virus VSV, des cellules hôtes qui servent à produire les virus et qui produisent des virions VSV pseudotypés, ainsi que l'utilisation de vecteurs mentionnés et des cellules destinées au traitement de tumeurs solides, notamment de tumeurs cérébrales.

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