C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A61K 35/76 (2006.01) A61K 39/165 (2006.01) A61K 39/20 (2006.01) A61K 39/295 (2006.01) C07K 14/12 (2006.01) C12N 7/08 (2006.01) C12Q 1/70 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2196238
A new attenuated substantially homogeneous Urabe mumps virus strain characterized by having a codon encoding glutamic acid at amino acid position 335 of the haemagglutinin-neuraminidase (HN) protein is provided. The codon may be GAA resulting in the abolition of an MseI restriction enzyme recognition site in the native virus. The invention also provides a gene encoding the HN (Glu-335) protein. The virus has utility in attenuated mumps vaccines, and as an antigen and immunogen in diagnostic embodiments.
ouvelle souche atténuée de virus des oreillons Urabe essentiellement homogène caractérisée par un codon codant l'acide glutamique à la position de l'acide aminé 335 de la protéine de l'hémagglutinine-neuraminidase (HN). Il est possible que le codon soit GAA, qui entraîne l'abolition d'un site de reconnaissance de l'enzyme de restriction MscI chez le virus natif. L'invention fournit aussi un gène codant la protéine HN (GLU-335). Le virus est utilisé dans les vaccins atténués contre les oreillons, et comme antigène et immunogène dans les applications diagnostiques.
Brown Earl G.
Dimock Kenneth D.
Wright Kathryn E.
Sim & Mcburney
Universite D'ottawa - University Of Ottawa
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