Simple and efficient hydrazinolysis of c-10 and c-13 ester...

Details Simple and efficient hydrazinolysis of c-10 and c-13 ester... Simple and efficient hydrazinolysis of c-10 and c-13 ester...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01)

Patent

CA 2403227

The present invention relates to a process for producing 10-deacetyl baccatin III from an acidic solution containing a spectrum of taxanes, which comprises contacting the acidic solution with a hydrazine hydrate, thereby to convert into 10-deacetyl baccatin III some taxanes in the solution that are not 10- deacetyl baccatin III. The present invention also provides a process for producing 10-deacetyl baccatin III from an acidic biomass extract, which comprises contacting the biomass extract with an appropriate solvent thereby to form an acidic solution, and contacting the solution with a hydrazine hydrate thereby to cleave the ester functionality of a taxane solute having an ester functionality on at least one of the C-10 and C-13 positions. Additionally, the present invention includes a process for producing 10- deacetyl baccatin III from a biomass extract, which comprises contacting the biomass extract with a mixture of a solvent and a hydrazine hydrate.

La présente invention concerne un procédé de production de 10-déacétyl baccatine III à partir d'une solution acide contenant un mélange complexe de taxanes, ce procédé consistant à mettre en contact la solution acide avec un hydrate d'hydrazine, pour convertir ainsi en 10-déacétyl baccatine III certains taxanes de la solution qui ne sont pas du 10-déacétyl baccatine III. La présente invention concerne également un procédé de production de 10-déacétyl baccatine III à partir d'un extrait de biomasse acide, ce procédé consistant à mettre en contact l'extrait de biomasse avec un solvant approprié pour former ainsi une solution acide, puis à mettre la solution en contact avec un hydrate d'hydrazine pour cliver la fonctionnalité ester d'un soluté de taxane ayant une fonctionnalité ester à au moins une des positions C-10 et C-13. La présente invention concerne également un procédé de production de 10-déacétyl baccatine III à partir d'un extrait de biomasse, ce procédé consistant à mettre en contact l'extrait de biomasse avec un mélange formé d'un solvant et d'un hydrate d'hydrazine.

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