Lasofoxifene tablet and its coating

Details Lasofoxifene tablet and its coating Lasofoxifene tablet and its coating

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 9/20 (2006.01) A61K 9/30 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2489407

Pharmaceutical compositions having uniform drug distribution and potency utilizing laxofoxifene as an active ingredient and containing a silicon dioxide to reduce loss of the active ingredient during the manufacturing process and methods for manufacturing such compositions are disclosed. The coating triacetin as plasticize was proven to confer good stability to lasofoxifene.

L'invention concerne des compositions pharmaceutiques présentant une répartition médicamenteuse uniforme et une capacité à utiliser le lasofoxifène en tant que principe actif et contenant un dioxyde de silicium pour réduire la perte du principe actif pendant le processus de fabrication. Cette invention concerne également des procédés permettant de fabriquer de telles compositions.

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