C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12M 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2702007
The present invention provides systems for measuring protein translation and methods for measuring overall transla-tion activity in viable cells or subcellular compartments. The methods of the present invention identify general ribosomal activity, if desired at sub-cellular resolution, thereby providing a signal indicating the rate of any of the steps of protein synthesis selected from initiation, elongation, termination or recycling. The translation system of the present invention can be used to identify translation modulators in high-throughput-screening (HTS).
La présente invention concerne des systèmes pour mesurer une translation de protéine et des procédés pour mesurer une activité de translation globale dans des cellules viables ou des compartiments sous-cellulaires. Les procédés de la présente invention identifient une activité ribosomique générale, si on le désire à une résolution sous-cellulaire, fournissant ainsi un signal indiquant la vitesse de l'une quelconque des étapes de synthèse protéique choisies parmi l'initiation, l'élongation, la terminaison ou le recyclage. Le système de translation de la présente invention peut être utilisé pour identifier des modulateurs de translation dans un criblage haut débit (HTS).
Anima Cell Metrology Inc.
Ridout & Maybee Llp
LandOfFree
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