Chiral arylketones in the treatment of neutrophil-dependent...

C - Chemistry – Metallurgy – 07 – C

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C07C 69/612 (2006.01) A61K 31/222 (2006.01) A61P 29/00 (2006.01) C07C 45/56 (2006.01) C07C 45/67 (2006.01) C07C 49/213 (2006.01) C07C 49/215 (2006.01) C07C 49/782 (2006.01) C07C 49/784 (2006.01) C07C 69/738 (2006.01) C07C 69/78 (2006.01) C07C 271/18 (2006.01) C07C 309/65 (2006.01) C07C 311/21 (2006.01) C07C 317/06 (2006.01) C07C 317/24 (2006.01) C07D 209/46 (2006.01) C07D 213/50 (2006.01) C07D 319/06 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2507765

ABSTRACT The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL- 8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

La présente invention concerne des composés de formule (I), dans laquelle Ar représente un noyau aromatique et Ra et Rb sont tels que définis dans la description. Ces composés sont utilisés en thérapie, en tant que médicaments pour traiter des maladies à médiation par des infiltrations de neutrophiles induites par IL-8, telles que le psoriasis, la polyarthrite rhumatoïde, la colite ulcéreuse et pour traiter des dommages causés par une ischémie et une reperfusion.

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