C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/167 (2006.01) A61K 31/7076 (2006.01) A61P 25/04 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2747658
This invention provides a method for inhibiting the release of interleukin- 1.beta. in a mammal. This invention also provides a method for preventing or treating pulmomary diseases, ophthalmic diseases, and autoimmune diseases that are associated with inflammation or inflammatory conditions. The invention also provides a method for preventing or treating neurodegenerative diseases, or pain in a mammal. The method comprises administering to a mammal in need thereof a therapeutically effective amount of a mononucleoside compound, which is an antagonist of P2X7 receptor.
La présente invention concerne une méthode d'inhibition de la libération d'interleukine-1 chez un mammifère. La présente invention concerne également une méthode permettant de prévenir ou de traiter des affections pulmonaires, ophtalmiques et auto-immunes associées à l'inflammation ou aux affections inflammatoires. L'invention concerne également une méthode permettant de prévenir ou de traiter des affections neurodégénératives, ou la douleur, chez un mammifère. Cette méthode comprend l'administration à un mammifère en ayant besoin d'une quantité thérapeutiquement efficace d'un composé de type mononucléoside, qui est un antagoniste du récepteur P2X7.
Boyer Jose L.
Decamp Jonathan Bryan
Douglass James G. III
Navratil Tomas
Samuelson Carl A.
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
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