Use of oxido-squalene cyclase inhibitors to lower blood...

Details Use of oxido-squalene cyclase inhibitors to lower blood... Use of oxido-squalene cyclase inhibitors to lower blood...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2226735

A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein G, T1, T2 and T3 are selected from CH and N; provided that T2 and T3 are not both CH; A is selected from a direct bond and (1-4C)alkylene; X is selected from oxy, thio, sulphinyl, sulphonyl, carbonyl, carbonylamino, N-di- (1-6C)alkylcarbonylamino, sulphonamido, methylene, (1-4C)alkylmethylene and di- (1-6C)alkylmethylene, and when T2 is CH, X may also be selected from aminosulphonyl and oxycarbonyl; and Q is selected from (5-7C)cycloalkyl, a heterocyclic moiety containing up to 4 heteroatoms selected from nitrogen, oxygen and sulphur; phenyl, naphthyl, phenyl(1-4C)alkyl and phenyl(2- 6C)alkenyl; for the manufacture of a medicament for treating diseases or medical conditions in which an inhibition of oxido-squalene cyclase is desirable.

On décrit un composé de la formule (I), ou un sel de celui-ci acceptable sur le plan pharmacologique. Dans cette formule G, T?1¿, T?2¿ et T?3¿ représentent CH ou N, à condition que T?2¿ et T?3¿ ne représentent pas tous deux CH; A représente une liaison directe ou alkylène(C¿1-4?); X est choisi dans le groupe constitué par oxy, thio, sulfinyle, sulfonyle, carbonyle, carbonylamino, N-dialkyl(C¿1-6?)carbonylamino, sulfonamido, méthylène, alkyl(C¿1-4?)méthylène et di-alkyl(C¿1-6?)méthylène, et lorsque T?2¿ représente CH, X peut représenter aminosulfonyle ou oxycarbonyle; et Q représente cycloalkyle(C¿5-7?), une fraction hétérocyclique contenant jusqu'à 4 hétéroatomes choisis parmi azote, oxygène et soufre; phényle, naphtyle, phényl-alkyle(C¿1-4?) et phényl-alcényle(C¿2-6?). Ce composé est destiné à la fabrication d'un médicament servant à traiter des maladies ou des états médicaux dans lesquels on souhaite inhiber les oxydo-squalènes cyclases.

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