C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/20 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) C07D 295/06 (2006.01) C07D 401/10 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01)
Patent
CA 2556268
The present invention relates to new acetylinic piperazine compounds of formula I, their pharmaceutically acceptable salts, and hydrates: Formula (I), wherein R1, R2, R3, R4, M, and n are as defined in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
L'invention porte sur de nouveaux composés acétyléniques de piperaient de formule (I) et sur leurs hydrates et leur sels pharmacocompatibles. Dans la formule (I), R?1¿, R?2¿, R?3¿, R?4¿, M, et n sont tels que définis dans la description. L'invention porte également les procédé de préparation desdits composés, sur des préparations pharmaceutiques les contenant et sur leurs utilisations thérapeutiques.
Bryan Chris
Isaac Methvin
Stefanac Tomislav
Astrazeneca Ab
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nps Pharmaceuticals Inc.
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