Cancerous disease modifying antibodies

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01)

Patent

CA 2557091

The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

L'invention concerne une méthode permettant la production d'anticorps modifiant l'évolution d'une maladie cancéreuse chez un patient à l'aide d'un nouveau paradigme de criblage. Cette méthode fait appel à une séparation des anticorps anticancéreux en utilisant la cytotoxicité contre les cellules cancéreuses comme critère de sélection, permettant ainsi de produire des anticorps anticancéreux à des fins thérapeutiques et diagnostiques. Ces anticorps peuvent être utilisés comme auxiliaires pour la détermination du stade et le diagnostic d'un cancer, et peuvent servir au traitement de tumeurs primitives et des métastases. Ces anticorps anticancéreux peuvent être conjugués à des toxines, à des enzymes, à des composés radioactifs et à des cellules hématogènes.

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