C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/496 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2707667
The present invention relates to novel amidomethyl-substituted oxindole derivatives of formula (I), pharmaceutical agents containing same, and the use thereof for the treatment of vasopressin-dependent illnesses. In formula (I), R1 is hydrogen, methoxy or ethoxy; R2 is hydrogen or methoxy; R3 is hydrogen, methyl, ethyl, n-propyl or isopropyl; and X1 and X2 are N or CH, with the proviso that X1 and X2 are not both N at the same time.
La présente invention concerne de nouveaux dérivés oxindoliques substitués par amidométhyle de formule (I), dans laquelle R1 = hydrogène, méthoxy ou éthoxy; R2 = hydrogène ou méthoxy; R3 = hydrogène, méthyle, éthyle, n-propyle ou isopropyle; X1 et X2 = N ou CH, à condition que X1 et X2 ne désignent pas N en même temps. L'invention concerne également des produits pharmaceutiques contenant ces dérivés et leur utilisation dans le traitement de maladies vasopressine-dépendantes.
Braje Wilfried
Geneste Herve
Hornberger Wilfried
Lubisch Wilfried
Netz Astrid
Abbott Gmbh & Co. Kg.
Torys Llp
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