G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/577 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2351562
A method for detecting neuronal cell damage, such as that caused by traumatic head injury, is disclosed. In this method, the amount of microtubule- associated protein 2(MAP-2) in the patient's body fluids is measured. This may be done, for example, by introducing to the fluid sample monoclonal antibody specific to MAP-2 and measuring the amount of complex formed. Kits used to carry out this method and the monoclonal antibodies used in those kits are also disclosed.
L'invention porte sur un procédé de détection des lésions des cellules nerveuses, telles que celles dues à un traumatisme crânien, consistant à mesurer dans des fluides corporels du patient la quantité de protéines 2 (MAP-2) associée aux microtubules. Cela peut par exemple se faire en introduisant dans un échantillon de fluide corporel des anticorps monoclonaux spécifiques de la MAP-2, puis en mesurant la quantité de complexe formée. L'invention porte également sur des trousses permettant de mener à bien le procédé et sur des anticorps monoclonaux utilisés dans ces trousses.
Zemlan Frank P.
Macpherson Leslie & Tyerman Llp
Zemlan Frank P.
LandOfFree
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