C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2623458
A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C- terminus and an N-terminus and a C-terminus amino acid and an N- terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the Cterminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptideblood component conjugate to assess the protection of the peptide from peptidase activity.
Bridon Dominique P.
Ezrin Alan M.
Holmes Darren L.
Milner Peter G.
Thibaudeau Karen
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Conjuchem Biotechnologies Inc.
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