C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/11 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2391369
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate- specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
L'invention concerne des compositions et des méthodes permettant de traiter et de diagnostiquer des cancers, tels que le cancer de la prostate. Ces compositions peuvent comprendre une ou plusieurs protéines spécifiques de la prostate, des parties immunogéniques de celles-ci ou des polynucléotides codant de telles parties. En variante, une composition thérapeutique peut comprendre un antigène présentant une cellule qui exprime une protéine spécifique de la prostate ou un lymphocyte T qui est spécifique des cellules exprimant une telle protéine. De telles compositions peuvent convenir, par exemple, pour la prévention ou le traitement de maladies telles que le cancer de la prostate. L'invention concerne également des méthodes de diagnostic basées sur la détection d'une protéine spécifique de la prostate ou de l'acide ribonucléique messager codant une telle protéine dans un échantillon.
Day Craig H.
Dillon Davin C.
Harlocker Susan L.
Jiang Yuqiu
Kalos Michael D.
Corixa Corporation
Gowling Lafleur Henderson Llp
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