Dna minor groove binding compounds

Details Dna minor groove binding compounds Dna minor groove binding compounds

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/404 (2006.01) A61K 31/427 (2006.01) A61P 31/00 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2470515

There is provided an oligopeptide compound comprising: (a) at least one nitrogen-containing basic group attached to at least one end of the oligopeptide; and (b) two or mor heterocyclic monomers, at least one of which is substituted in the heterocyclic part by a branched, cyclic or part cyclic C3-5 alkyl group, or a pharmaceutically acceptable salt or solvate thereof; which compound, salt or solvate binds to the minor groove of DNA.

L'invention a trait à un composé oligopeptide comprenant : (a) au moins un groupe basique contenant du nitrogène fixé à au moins une extrémité de l'oligopeptide ; et (b) au moins deux monomères hétérocycliques, dont au moins un est substitué dans la partie hétérocyclique par un groupe alkyle C¿3-5? cyclique ou en partie cyclique ramifié, ou un sel ou un solvate de celui-ci pharmaceutiquement acceptable. Ledit composé, sel ou solvate se lie au petit sillon de l'ADN.

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